可注射,抗菌和释放氧气的基托桑基水凝,用于细菌感染伤口的多式治愈
Shayesteh Bochani1,2, Atefeh Zarepour3, Ali Kalantari-Hesari4
1Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran. maleki@zums.ac.ir.
Journal of materials chemistry. B
|August 7, 2023
概括
这项研究开发了一种新的基托基水凝,具有抗菌和抗炎性质. 新材料通过减少感染和炎症,有效促进伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 纳米技术纳米技术
背景情况:
- 细菌感染使伤口愈合复杂化,增加医疗保健成本.
- 抗生素耐药性需要替代治疗策略.
- 多功能材料为先进的伤口护理提供了有希望的解决方案.
研究的目的:
- 开发一种新的抗菌,多功能水凝,用于伤口愈合.
- 结合化学动力学和光热特性,增强治疗效果.
- 为应对抗生素耐药细菌在伤口管理中所带来的挑战.
主要方法:
- 制造一种基托 (CT) 基的水凝,其中包含酸 (TA),铁 (Fe) 和二氧化 (MnO2) 的纳米片 (CT-TA-Fe-MnO2).
- 描述水凝的物理和化学特性.
- 在体外和体内对抗菌,抗炎和伤口愈合能力的评估.
主要成果:
- 该CT-TA-Fe-MnO2水凝通过活性氧物种生成在体外表现出显著的抗菌活性.
- 在体内研究显示,降低了静血时间,改善了抗炎作用.
- 观察到加快伤口愈合,14天内增强原沉积和成熟的证据.
- 没有注意到对重要器官的不良影响.
结论:
- 制造的CT-TA-Fe-MnO2水凝具有强大的抗菌和抗炎性质.
- 这种多功能水凝是有效的伤口愈合应用的有希望的候选者.
- 协同作用的化学动力学和光热特性有助于其治疗疗效.
相关概念视频
Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
Cleaning, Sterilization, and Disinfection
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Methods of Sterilization II: Chemical Methods
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Chemical Agents for Microbial Control
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Bacterial Toxins
Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...


