在体重较高的女性中,动态的前-桃体相互作用是情绪调节缺陷的基础
Pablo Maturana-Quijada1, Trevor Steward2,3, Nuria Vilarrasa4,5
1Psychiatry and Mental Health Group, Neuroscience Program, Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
Obesity (Silver Spring, Md.)
|August 7, 2023
概括
体重指数 (BMI) 高的个体表现出大脑连接的改变,影响情绪调节. 这项研究揭示了肥胖时前额叶皮层抑制杏仁体的减少,阻碍了负面情绪的控制.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 医疗成像医学成像
背景情况:
- 情绪调节涉及前额叶皮层对像杏仁体这样的皮质下区域的调节.
- 患有肥胖症的个体可能在情感任务期间表现出前额前部调节系统的低活性.
- 在肥胖和情绪调节中,前-桃体通路的方向性需要进一步研究.
研究的目的:
- 在成年女性的认知重新评估期间,比较前-桃体有效连接,肥胖与对照.
- 研究身体质量指数 (BMI) 对参与情绪调节的神经通路的影响.
主要方法:
- 使用功能磁共振成像 (fMRI) 和动态因果建模 (DCM).
- 绘制了前额前部区域 (背中侧PFC,轨道前额PFC,背侧PFC) 与杏仁体之间的有效连接.
- 采用参数实证贝叶斯来分析连接模型.
主要成果:
- 肥胖组报告了更高的情绪调节难度评分.
- 一个自上而下的皮质模型最好地解释了fMRI数据.
- 在重新评估期间,较高的BMI与轨道前皮层和背中前皮层对杏仁核活动的抑制效果较差有关.
- 较低的BMI与增加的背侧前额叶皮质到杏仁体刺激调节相关.
结论:
- 这些发现支持一个模型,其中改变的前-桃体连接有助于高体重个体的情绪调节困难.
- 这些神经差异可能是管理与肥胖相关的负面影响的挑战的基础.
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