pH-可激活的铜-阿克西替尼布协调的多功能纳米颗粒用于对抗侵袭性癌症的协同化学化学动力学疗法
Muse Ji1, Hongbing Liu1, Hanxun Wang2
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. pharmzy@163.com.
Biomaterials science
|August 7, 2023
概括
这项研究引入了结合化学动力学疗法 (CDT) 和化疗的新型纳米粒子,以有效地杀死癌细胞. 新的治疗方法显示出显著的瘤抑制,具有良好的生物相容性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 化学动力学疗法 (CDT) 通过通过芬顿反应产生基激素 (̇OH) 来治疗癌症.
- CDT的有效性通常受到瘤微环境 (TME) 的限制,包括谷氨 (GSH) 的过度表达和低反应效率.
研究的目的:
- 开发一种可pH激活的纳米粒子系统 (Cu-AXB NPs),结合CDT (Cu2+) 和化疗 (axitinib,AXB) 来克服TME的局限性.
- 通过协同效应和改进的准来增强瘤细胞杀伤.
主要方法:
- 制造具有高药载荷 (87.55%) 和受控大小 (~180 nm) 的Cu-AXBNP.
- 评估纳米粒子稳定性,pH响应性药物释放,以及协同治疗效应在体外和体内.
- 在携带瘤的小鼠中评估瘤向,抑制率和生物相容性.
主要成果:
- 在酸性TME中,Cu-AXB NPs表现出卓越的血稳定性和向性药物释放.
- 这些纳米粒子通过芬顿式反应有效地产生OH,并破坏了铜代谢,增强了CDT.
- 结合疗法导致优异的瘤细胞杀死,显著的瘤抑制 (77.53%) 和良好的生物相容性.
结论:
- 通过协同结合CDT和化疗,Cu-AXBNP为癌症治疗提供了一个有希望的策略.
- 开发的系统有效地向瘤,提高治疗结果,同时保持安全.
- 这种方法代表了瘤治疗的潜在突破.
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