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Andrew Jack¹, Mithun Rajshekar², Christopher D Witiw³

¹Division of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

|August 7, 2023

概括

神经移植 (NT) 可能会使许多患有创伤性脊髓损伤 (tSCI) 的患者受益. 这项研究确定了TSCI患者适合NT的流行病学和损伤特征,有助于治疗选择.

科学领域:

神经外科神经外科
再生医学是一种再生医学.
流行病学流行病学

背景情况:

创伤性脊髓损伤 (tSCI) 经常导致不可逆转的衰弱.
像神经转移 (NT) 这样的新策略对于减轻二次损伤和增强功能至关重要.
对于有资格接受NT的SCI患者,流行病学数据有限.

研究的目的:

描述STSI患者的流行病学和受伤相关方面.
确定可以从NT中受益的SsCI个人的数量和类型.
为了告知患者选择NT干预的信息.

主要方法:

评估了2005-2019年期间入院的宫SCI (C1-T1) 的成年人 (<80岁).
两个独立的外围神经专家根据特定的神经学标准 (捐赠者MRC≥4/5,接受者≤2/5) 确定了对NT的适合性.
人口,创伤和神经学变量被收集和分析.

主要成果:

在709名SCI患者中,224名 (32%) 符合最初的选择标准.
108名患者 (15%的所有tSCIs,48%的宫tSCIs) 被确定为合适的NT候选人.
随着时间的推移,由于神经恢复或神经变化,患者的NT资格波动.

结论:

很大一部分患有宫SCI的个体是NT的潜在候选人.
这项研究提供了从大型前数据库中对符合NT条件的tsci患者人数的首次详细分析.
这些发现可以指导NT的应用,以改善SCI患者的功能结果.

关键词:

脊髓损伤导致的脊髓损伤临床流行病学临床流行病学神经的再生神经的再生神经外科神经外科手术

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