梅西马在患有严重甲状腺功能障碍相关的严重肝功能障碍患者中的临床表现和早期疗效
Chen Li1,2, Kai-Li Wang1,2, Jin-Hua Hu1,2
1Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Scandinavian journal of gastroenterology
|August 7, 2023
概括
这项研究发现,低剂量甲基马 (MMI) 是安全有效的治疗严重的肝功能障碍 (SHD) 患者的高甲状腺症 (GH). 治疗MMI导致肝功能标志物和临床症状显著改善.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 格雷夫斯甲状腺功能障碍 (GH) 可以导致肝损伤,但严重的肝功能障碍 (SHD) 是罕见的.
- 在SHD的GH患者中使用甲基马 (MMI) 是有争议的.
- 本研究研究了与GH相关的SHD的临床特征和MMI疗效.
研究的目的:
- 为了确定与Graves的甲状腺功能障碍相关的严重肝功能障碍患者的临床特征.
- 评估低剂量甲基马 (MMI) 在治疗这些患者中的安全性和有效性.
主要方法:
- 从2017年1月到2022年7月,对33名与GH相关的SHD患者进行了回顾性研究.
- 评估临床表现,治疗反应和MMI有效性.
- 治疗MMI和非MMI组之间的结果比较.
主要成果:
- 常见的症状包括黄,黄色的尿液,疲劳和.
- 低剂量MMI治疗显著降低了甲状腺激素和肝酶 (p < .05).
- 与非MMI组 (9.5%,p = .001) 相比,MMI组的改善率 (77.8%) 较高,MMI是早期改善的独立预测因素.
结论:
- 与GH相关的SHD的临床表现主要与肝脏有关.
- 低剂量甲基马 (MMI) 是一个安全有效的治疗严重的肝功能障碍在Graves的甲状腺功能障碍患者.
- 治疗MMI与改善的临床结果和肝功能有关.
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