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在印度中部的一家三级医疗中心的格兰氏阴性晚期新生儿败血症:回顾性分析
Akangksha Pataskar1, Anuragsingh Chandel2, Varsha Chauhan2
1MGIMS, Sevagram, Maharashtra, India.
Clinical medicine insights. Pediatrics
|August 7, 2023
概括
新生儿晚发性败血症正在增加,格拉姆阴性细菌构成重大威胁. 这项研究发现了Klebsiella spp. 作为一个共同的原因,突出了针对性抗生素战略的需要.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 新生儿败血症仍然是全球死亡和发病的主要原因.
- 晚发性败血症 (LOS) 正在增加,因为早产婴儿的生存率有所改善.
- 格拉姆阴性细菌在新生儿败血症中越来越令人担忧,特别是在印度.
研究的目的:
- 调查新生儿格兰氏阴性晚发性败血症的临床特征和结果.
- 在印度中部的一个三级护理中心,识别导致LOS的常见格兰负病原体.
主要方法:
- 从2019年1月到2021年12月,对28天以下的新生儿怀疑LOS的回顾性分析.
- 收集和分析临床表现,致病生物和结果 (出院或死亡) 的数据.
主要成果:
- 格拉姆阴性LOS的患病率为4.8%.
- 常见的临床症状包括呼吸困难 (52.2%),发作 (18.9%),黄和昏迷.
- 克莱布西埃拉 spp. 的种类. (36.7%) 是最常见的分离物,其次是Acinetobacter spp. (31.1%) 和大肠杆菌 (17.8%).
- 低妊娠年龄和低出生体重与糟糕的结果有关.
- 格拉姆阴性LOS的整体死亡率为30%.
结论:
- 格拉姆阴性细菌,特别是Klebsiella spp.,是新生儿晚发性败血症的重要病原体.
- 过早生育和低出生体重是新生儿格兰负性败血症不良结果的危险因素.
- 经验性抗生素政策应涵盖诸如Klebsiella spp.等常见的细菌阴性生物. 为了有效的管理.
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