重构代谢与NLRP3炎症酶之间的联系:治疗机会
Miguel A Ortega1,2, Diego De Leon-Oliva1,2, Cielo García-Montero1,2
1Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Spain.
Frontiers in immunology
|August 7, 2023
概括
对于免疫力至关重要的NLRP3炎症酶在两个阶段被激活,并通过各种修饰和代谢信号进行调节. 了解这些机制有助于开发针对免疫和代谢疾病的向疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 代谢过程中的代谢.
背景情况:
- 炎症体是细胞质蛋白质复合体,可以感知危险信号.
- 核酸结合的寡合化域,含有3 (NLRP3) 炎症体的氨酸丰富的重复含有家族氨酸域,已得到充分研究.
- NLRP3的激活包括原始化和激活步骤,导致IL-1β/IL-18分泌和热.
研究的目的:
- 审查NLRP3炎症体的结构,功能,激活和调节.
- 强调线粒体功能障碍,mtROS产生和代谢信号在NLRP3调节中的作用.
- 讨论当前的NLRP3抑制剂及其作用机制.
主要方法:
- 关于炎症性研究的文献综述.
- 对调节NLRP的翻译后修改进行分析3.
- 检查影响NLRP3激活的代谢途径.
主要成果:
- 激活NLRP3是一个复杂的,多步骤的过程.
- 翻译后的修改显著控制了NLRP3活动.
- 线粒体功能障碍和代谢信号是NLRP3.3的关键调节者.
结论:
- 了解NLRP3调节对于开发新疗法至关重要.
- 准NLRP3为免疫和代谢疾病提供了潜在的治疗方法.
- 对NLRP3抑制剂的进一步研究是有必要的.
相关概念视频
02:26NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
01:31Regulation of the Unfolded Protein Response
2.5K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.5K