在SARS-CoV-2和Mycobacterium tuberculosis联合感染中抑制性髓状细胞
Jane Alexandra Shaw1, Stephanus T Malherbe1, Gerhard Walzl1
1Department of Science and Technology/National Research Foundation (DSI-NRF) Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Frontiers in immunology
|August 7, 2023
概括
结核病和COVID-19的联合感染增加了死亡风险. 骨髓原抑制细胞 (MDSC) 可能通过在两种感染中广泛抑制免疫来解释这种双重威胁.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 病理生理学 病理生理学
背景情况:
- 结核病 (TB) 和冠状病毒疾病-2019 (COVID-19) 的联合感染增加了死亡风险.
- 这两种感染都涉及免疫失调,但具体的共享机制尚不清楚.
- 最初对T细胞免疫的关注已经扩大到包括COVID-19中的先天性免疫功能障碍.
研究的目的:
- 探索骨髓原抑制细胞 (MDSC) 在结核病-COVID-19联合感染的不良结果中的作用.
- 调查MDSC作为潜在的共同机制,将结核病和SARS-CoV-2严重程度联系起来.
主要方法:
- 审查现有的结核病和COVID-19的流行病学和免疫学数据.
- 在严重的COVID-19中分析先天性免疫反应,包括髓状细胞子集.
- 检查MDSC在结核病和COVID-19病原发生中的作用.
主要成果:
- 严重的COVID-19与免疫抑制性MDSC的数量增加有关.
- MDSC与结核病中Mycobacterium结核病 (Mtb) 的控制受损有关.
- 功能障碍的先天免疫,包括MDSC扩张,在严重的COVID-19中观察到.
结论:
- 骨髓原抑制细胞 (MDSC) 是一个关键的共享机制,在结核病-COVID-19联合感染中导致不良临床结果.
- MDSC有助于免疫抑制,阻碍细菌和病毒感染中的病原体清除.
- 针对MDSC可能为同时感染的患者提供治疗策略.
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