轻度创伤性脑损伤史与士兵的下脑网络弹性有关
Jacob R Powell1, Joseph B Hopfinger2, Kelly S Giovanello2
1Matthew Gfeller Center, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Brain communications
|August 7, 2023
概括
士兵的轻度创伤性脑损伤史与大脑网络分类性降低有关,这表明大脑网络的弹性较低. 这可能标志着未来的神经风险,即使没有目前的症状.
科学领域:
- 神经科学是一个神经科学.
- 脑损伤研究 脑损伤研究
- 神经成像中的图形理论
背景情况:
- 特别行动部队 (SOF) 的士兵经常经历轻微创伤性脑损伤 (mTBI) 由于爆炸和重物.
- 重复的mTBI可以导致持续的行为,认知,情绪和神经问题.
- 检测mTBI后的神经生理变化,即使没有当前症状,对于识别未来的神经风险至关重要.
研究的目的:
- 通过使用图形理论,调查mTBI史,终身发病率和近期对全脑网络连接的影响.
- 在没有当前症状的健康SOF士兵中识别与mTBI相关的神经生理标记.
主要方法:
- 涉及健康男性SOF士兵的横截面研究.
- 使用3T核磁共振扫描仪进行多式神经成像.
- 使用图形理论 (全球效率,局部效率,分类系数) 通过大脑连接工具箱分析的功能性MRI数据.
主要成果:
- 与没有mTBI史的士兵相比,具有mTBI史的士兵表现出明显较低的分类系数.
- 较高的mTBI终身发病率显著预测了较低的分类性.
- 没有发现大脑网络效率 (全球或本地) 或mTBI近期组之间的显著差异.
结论:
- 较低的分类性表明,在有mTBI史的士兵中,大脑网络不那么有弹性,更容易受到伤害.
- 脑网络弹性降低,由较低的分类性表明,可能预测未来的神经功能障碍和加速的神经退行.
- 需要进行纵向研究来确认大脑网络弹性下降是否是长期神经结果的预测因素.
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