了解患有自闭症和典型发育的儿童肠道微生物群,饮食摄入量和营养状况之间的联系
Paula Mendive Dubourdieu1, Marcela Guerendiain1
1Área de Investigación, Escuela de Nutrición, Universidad de la República, Montevideo, Uruguay.
Frontiers in nutrition
|August 7, 2023
概括
自闭症谱系障碍 (ASD) 与肠道细菌的差异有关. 与典型的发育同龄人相比,患有自闭症和超重症的儿童表现出明显的微生物特征和与饮食的关联.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 人们越来越认识到肠道微生物群的组成对人类健康和各种疾病的作用.
- 自闭症谱系障碍 (ASD) 是肠道微生物组可能发挥重要作用的疾病之一.
研究的目的:
- 分析患有自闭症谱系障碍 (ASD) 和典型发育 (TD) 的儿童的肠道细菌组成.
- 研究这些儿童的肠道微生物群,营养状况 (体重指数-年龄z-score) 和饮食摄入量之间的关系.
主要方法:
- 一项描述性的横截面研究,涉及3至12岁的儿童 (30有自闭症,28TD).
- 通过食物频率问卷评估的饮食摄入量;根据BMI-for-age z-score确定营养状况.
- 在便样本中使用16S rRNA测序分析肠道细菌,ASD组进一步按饮食分类 (无质和素与无饮食).
主要成果:
- 与正常体重儿童相比,超重儿童的 *Roseburia * 水平较低.
- 与TD组相比,ASD组表现出较少的Bifidobacterium longum和更高的Clostridium glycolicum.
- 与营养状况相似的TD儿童相比,患有超重和ASD的儿童的Roseburia*和Faecalibacterium prausnitzii*较低,Eubacterium ventricosum*和Flavonifractor plautii*较高. 观察到特定细菌与摄入乳制品,蔬菜,谷物,蛋白质,鱼,脂肪和子油之间存在关联.
结论:
- 患有ASD和TD的儿童之间存在肠道微生物社区组成的显著差异.
- 这些差异受到营养状况和特定的饮食摄入模式的影响.
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