在婴儿的肠道解剖手术后早期口服养:一个多中心的真实世界研究
Changgui Lu1, Xinhe Sun2, Qiming Geng1
1Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in nutrition
|August 7, 2023
概括
儿科肠道解后的早期口服养 (EOF) 是安全有效的,减少了住院时间和亲肠营养的使用. 诸如解位和婴儿体重等因素会影响EOF的发生率,但不会增加严重的并发症.
科学领域:
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
背景情况:
- 延迟口服养 (DOF) 是标准的儿科肠道解肠术后手术,以预防并发症.
- 早期口服养 (EOF) 显示出减少并发症和加速恢复的前景.
- 在接受IA的婴儿中,EOF安全性和有效性的证据有限.
研究的目的:
- 评估早期口服养 (EOF) 的安全性和有效性,用于肠道缩 (IA) 后的婴儿.
- 评估EOF的当前应用状态,并确定影响其实施的因素.
主要方法:
- 总共分析了898名婴儿,比较了EOF (n=182) 和DOF (n=716) 组.
- 倾向性得分匹配 (PSM) 用于平衡安全性和疗效比较的基线数据 (EOF n=179,DOF n=319).
- 多变量后勤回归确定了与EOF实施相关的因素.
主要成果:
- 在IA的婴儿中,EOF的总比率为20.3%.
- 解位和手术时的婴儿体重是影响EOF率的重要因素.
- EOF组的总体门营养 (TPN),门营养 (PN) 和住院时间显著缩短 (所有p<0.001).
- 虽然腹部张张和吐在EOF组中较高 (p<0.001,p=0.006),但道泄漏和其他严重并发症的发生率没有显著差异.
结论:
- 在肠道解 (IA) 后的婴儿早期口服养 (EOF) 是安全有效的,尽管整体实施率较低.
- EOF减少了对PN的需求,并缩短了住院时间,而不会增加严重的并发症.
- 解位和婴儿体重是影响EOF采用的关键因素.
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