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在头部和部状细胞癌中S100蛋白 (综述)

Yihong Hu^1,2, Yucheng Han^1,2, Minhui He^1,2

¹Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Guilin Medical University, Guilin, Guangxi 541004, P.R. China.

Oncology letters

|August 7, 2023

概括

S100蛋白与头部和部状细胞癌 (HNSCC) 的发展和进展有关. 准这些S100蛋白可能为HNSCC预防,诊断和治疗提供新的策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

头部和部状细胞癌 (HNSCC) 是一种流行癌症,具有具有挑战性的临床特征.
HNSCC呈现出迅速发病,诊断困难,耐药性和不良影响,妨碍有效管理.
新兴研究突出显示S100蛋白与HNSCC之间存在显著的关联.

研究的目的:

审查S100蛋白在HNSCC的启动和进展中的多方面的作用.
探索S100蛋白在关键细胞过程中的参与,与HNSCC相关.
讨论S100蛋白作为HNSCC的诊断和治疗点的潜力.

主要方法:

对研究S100蛋白质和HNSCC.研究的文献综述.
对S100蛋白参与细胞循环调节,癌症干细胞特性和迁移的分析.
在HNSCC中检查S100蛋白与信号通路 (例如Hippo,NF-κB,PI3K/Akt/mTOR) 的相互作用.

主要成果:

特定的S100蛋白 (S100A8,S100A9,S100A14) 通过细胞循环阻断抑制瘤细胞的增殖.
通过与actin和tropomyosin相互作用,S100A4促进了HNSCC的迁移.
多个S100蛋白 (S100A1,S100A8,S100A9,S100A10,S100A14,S100P) 通过各种信号通路参与HNSCC的启动和进展.
长非编码RNA和微RNA调节HNSCC中的S100蛋白表达.
某些S100蛋白的下调可能会改善HNSCC的化学敏感性.

结论:

S100蛋白在HNSCC发育中起着至关重要的作用,影响繁殖,迁移和茎状.
通过与关键信号通路的相互作用,S100蛋白质参与HNSCC病变发生.
S100蛋白质代表了HNSCC预防,诊断和治疗的有希望的生物标志物和治疗点.

关键词:

在S100蛋白质中.头部和部状细胞癌瘤人类乳头瘤病毒人类乳头瘤病毒口腔状细胞癌的癌症.病变的发生和发病.

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