肝硬化中的肉类:针对肠道微生物群的治疗前景
Roman Maslennikov1,2, Aliya Alieva1, Elena Poluektova1,3
1Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow 119435, Russia.
World journal of gastroenterology
|August 7, 2023
概括
肉症是肝硬化患者常见的疾病,与肠道肌肉轴的破坏有关. 针对肠道的药物有望改善这一轴,但需要进一步的临床试验来治疗肉症.
科学领域:
- 胃肠病学和肝病学
- 肌肉生理学 肌肉生理学
背景情况:
- 肉症 (肌肉质量和功能下降) 在肝硬化患者中很普遍,与不良结果相关.
- 肠-肌肉轴,涉及肠道屏障功能,失生症和小肠细菌过度生长 (SIBO),涉及到sarcopenia的致病性.
- 像氨,LPS,炎症调解剂和肌素这样的因素受到肠道失调的影响,会对肌肉健康产生负面影响.
研究的目的:
- 探索肠道肌肉轴在肝硬化相关的肉症中的作用.
- 审查向肠道微生物群的药物在治疗肝硬化中的肉类的潜力.
主要方法:
- 在肝硬化中关于肠肌轴的文献综述.
- 分析影响肠道微生物群的药物干预及其对肠道肌肉轴的影响.
主要成果:
- 肠道失调和SIBO有助于增加影响肌肉的有害物质水平.
- 药物干预 (例如,利法西明,乳糖,益生菌) 显示出通过减少高氨血,炎症和细菌转移来改善受损的肠肌轴的潜力.
- 目前的证据是有限的,没有专门用于治疗/预防肉硬化症的随机对照试验.
结论:
- 肠-肌肉轴是肝硬化相关的肉症的一个关键因素.
- 肠道向疗法为治疗肝硬化症中肉类的治疗提供了一个有希望的途径,需要进一步调查.
- 便移植在临床前模型中显示出潜力,但需要临床评估.
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