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在根性囊中表达P63和Ki-67

Mohammed Amjed Alsaegh¹, Okba Mahmoud^2,3, Sudhir Rama Varma^2,3

¹Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Journal of oral biology and craniofacial research

|August 7, 2023

概括

在根性囊 (RCs) 中,P63蛋白高度表达. 它在质表皮中的表达与炎症有负相关性,但与囊大小或细胞增殖无关.

科学领域:

口腔病理学口腔病理学
分子生物学分子生物学
免疫组织化学免疫组织化学

背景情况:

根性囊 (RCs) 是一种炎症性下囊.
P63是一种转录因子,对上皮细胞的发育和维护至关重要.
了解RCs中的P63表达可能会阐明囊的病原性.

研究的目的:

为了研究根性囊中的P63表达.
为了将P63表达与上皮质细胞增殖 (Ki-67) 的相关性.
评估P63与炎症透症严重程度和RC大小之间的关系.

主要方法:

对30个根性囊样本进行了回顾性横截面研究.
免疫组织化学用于检测P63和Ki-67的表达.
统计分析以将标记物表达与临床病理特征相关联.

主要成果:

在RCs的质表皮和结缔组织囊中观察到高P63表达.
在Ki-67 (扩散标志物) 和P63表达之间没有发现相关性.
在Ki-67和RC尺寸之间发现了正相关性.
炎症透和P63表达在odontogenic上皮质之间的负相关性.
炎症透和RC大小之间的负相关性.

结论:

在根性囊中,P63的表达很高.
在odontogenic表皮中的P63表达与炎症透相反相关.
P63表达与上皮细胞增殖或RC大小无关.

关键词:

在 Ki-67 机器人臭臭症引起的臭臭性 P63 P63 是一个核武器的扩散根性囊是一个根性囊.

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