在α-synucleinopathies的性别差异:一个系统的审查
Kausar Raheel1, Gemma Deegan1,2, Irene Di Giulio1,3
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Frontiers in neurology
|August 7, 2023
概括
男人表现出更高的患病率和严重程度的α-synucleinopathies,表明女性激素可能是神经保护的. 本综述探讨了这些神经退行性疾病中的性别和性别差异.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 在男性中,α-synucleinopathies表现得更严重,暗示着雌激素等女性激素的潜在神经保护.
- 在α-synucleinopathies中这些基于性别的差异背后的精确机制在很大程度上是未知的.
- 这一系统性审查批判性地评估了目前关于α-synucleinopathies的性别和性别差异的证据.
研究的目的:
- 系统地审查和批判性地评估有关alpha-synucleinopathies的性别和性别差异的当代证据.
- 从长椅到床边的角度综合发现.
主要方法:
- 对2012年至2022年间发表的研究进行系统审查.
- 在PubMed,Embase和Ovid数据库中进行的搜索.
- 包括关于快速眼动 (REM) 行为障碍 (RBD),帕金森病 (PD),勒维体痴呆症 (DLB) 和多系统缩 (MSA) 的研究.
主要成果:
- 包括162项研究 (5项RBD,6项MSA,20项DLB,131项PD).
- 确的证据支持在α-synucleinopathies中跨人口统计,生物标志物,遗传学,临床特征,干预措施和生活质量方面的性别和性别特异性表现.
- 关于特定的性激素作用的数据有限,重点是雌激素的潜在神经保护作用.
结论:
- 在各种α-synucleinopathies中存在显著的性别和性别差异.
- 进一步的研究对于阐明性别特异性机制至关重要.
- 了解这些机制对于开发针对性,性别特异性疗法至关重要.
更多相关视频
12:01Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
Published on: May 30, 2015
10.8K
08:33Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
8.3K
相关概念视频
01:37Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
01:15Parkinson's Disease: Overview
598
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
598