过氧化物通过自调节和炎症抑制减轻败血症诱导的急性肺损伤 (ALI)
Jingyin Mai1, Qingqing He2, Yuting Liu3
1Emergency Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai 200071, China.
Mediators of inflammation
|August 7, 2023
概括
过氧化物 (HYP) 治疗改善了生存率,并减少了因败血症引起的急性肺损伤 (ALI) 的炎症. HYP通过调节自和蛋白Atg13来保护肺细胞,提供了一个潜在的治疗策略.
科学领域:
- 炎症和免疫学 炎症和免疫学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 败血症相关的急性肺损伤 (ALI) 显著增加死亡率和发病率.
- 过氧化物 (HYP) 在各种条件下表现出抗炎性质.
- HYP对败血症诱导的ALI的保护作用在很大程度上仍未被探索.
研究的目的:
- 调查超酸 (HYP) 在减轻败血症引起的急性肺损伤 (ALI) 中的治疗潜力.
- 阐明潜在的分子机制,包括自和Atg13在HYP的保护作用中的作用.
主要方法:
- 一个结刺 (CLP) 鼠标模型被用于诱导败血症和ALI.
- 蛋白质组学,免疫组织化学,免疫光学和ELISA被用来分析肺组织.
- 人类肺微血管内皮细胞 (HLMVEC) 用于体外LPS诱导损伤实验.
主要成果:
- 在败血症-ALI小鼠模型中,HYP治疗增加了生存率,减少了炎症因素,并减少了肺组织亡.
- 在败血性肺组织中,HYP恢复了血管生成,并减轻了LPS诱导的HLMVEC损伤.
- 蛋白质组学发现Atg13对HYP的保护作用至关重要,通过自调节进行调节.
结论:
- 过酸 (HYP) 有效地减轻了败血症引起的急性肺损伤 (ALI).
- HYP通过调节自和抑制炎症来发挥其保护作用,其中Atg13起着关键作用.
- HYP显示出作为治疗性治疗剂的前途,用于败血症诱导的ALI.
相关概念视频
01:28Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:27Autophagy
4.3K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.3K