性别之间的近道泌尿道上腺体受体的差异
Po-Chun Hsieh1, Shang-Jen Chang2,3, Hsi-Hsien Chang2
1Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Tzu chi medical journal
|August 7, 2023
概括
贝塔-上腺体受体主导女性近道尿道光滑肌收缩. 阻止这些受体可能为女性排泄功能障碍提供一种新的治疗方法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 膀和尿道形成了尿的功能单位.
- 性差异存在于尿道光滑肌 (USM) 对上腺刺激的反应.
- 了解这些差异对于治疗排空功能障碍至关重要.
研究的目的:
- 研究上腺素受体在雄性和雌性小鼠近端尿道中的作用.
- 阐明尿道光滑肌收缩和放松的性别特异性机制.
主要方法:
- 从雄性和雌性C57BL/6小鼠的尿膀和近端尿道光滑肌的隔离和器官浴安装.
- 评估乙胆和上腺激动剂 (上腺素,上腺素) 诱导的收缩.
- 对NG-nitro-L-arginine,利多卡因和素的抑制作用的评估.
主要成果:
- 上腺素和诺上腺素在低度时诱导了最小的收缩,但在较高度时在女性近端USM中诱导了放松阶段.
- 这种放松是由NG-nitro-L-arginine,利多卡因和素抑制的,这表明感觉和性神经的参与.
- 上腺素诱导的收缩被propranolol增强,这表明女性近端USM中β-上腺受体具有主导作用.
结论:
- 贝塔-上腺素受体可能是女性近道尿道光滑肌中的主导受体.
- 感觉和性神经的活动可能会对女性近端尿道产生抗收缩作用.
- 贝塔-上腺素受体抑制剂显示出治疗女性排泄功能障碍的潜力.
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