循环金属化 (III) 复合物与可纳结合:抗菌活性对抗耐药性C. 阿尔比班人
Jun-Jian Lu1, Zhi-Chang Xu2, Hou Zhu1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Frontiers in cellular and infection microbiology
|August 7, 2023
概括
(III) 复合物Ir2和可纳的组合显示出强大的抗真菌活性,对抗药物耐药的Candida albicans. 这种组合疗法抑制了真菌生长和生物膜的形成,为治疗耐药真菌感染提供了一个有前途的策略.
科学领域:
- * 无机化学 无机化学
- * 医学化学 医学化学
- * 菌群学 * 菌群学
背景情况:
- * *Candida albicans* (*C. albicans*) 是一种常见的引起感染的真菌病原体.
- *C. albicans的耐药性需要新的治疗策略.
- *组合疗法是对抗抗真菌耐药性的新兴方法.
研究的目的:
- *合成和评估循环金属化 (III) 和多 (II) 复合物.
- * 调查这些复合物的抗真菌活性对抗耐药的C. albicans.
- *评估这些复合物与可纳 (FLC) 结合时的协同效应.
主要方法:
- *合成 (III) 复合物 (C-N) 和 (II) 复合物 (RuN-N) 的合成.
- *对抗药物耐药的C. albicans菌株进行抗真菌敏感性测试.
- * 评估与可纳 (FLC) 的联合治疗.
- * 机理研究包括菌/生物膜抑制,线粒体功能评估和反应性氧物种 (ROS) 检测.
主要成果:
- *与FLC结合的 (III) 复合物Ir2显示出对耐药C. albicans*具有显著的抗真菌活性.
- *这种组合有效地抑制了菌和生物膜的形成.
- *协同效应与线粒体功能障碍和细胞内ROS积累增加有关.
结论:
- * (III) 复合物,特别是Ir2,作为FLC治疗耐药性*C. albicans*感染的辅助剂,显示出有前途.
- *与Ir2和FLC结合治疗提供了一种潜在的策略,以提高治疗疗效.
- *观察到的机制涉及破坏真菌形态和细胞过程.
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