用辅助局部或口服类固醇治疗的眼球梅毒患者视觉敏度结果的评估
Rhys Ishihara1, Seth Buscho1, Hannah J Yu1
1Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, USA.
Cureus
|August 7, 2023
概括
与局部类固醇相比,口服类固醇显著改善了眼球梅毒患者的视力. 与青素一起服用类固醇的时间没有影响视力敏度的结果. 这项研究强调口服类固醇作为潜在的优越的辅助治疗眼球梅毒.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼球梅毒是一种严重的感染,影响视力.
- 辅助类固醇在眼球梅毒治疗中的作用仍在争论中.
- 青素是主要的治疗方法,但炎症管理至关重要.
研究的目的:
- 评估用青素和辅助类固醇治疗眼球梅毒患者的临床结果.
- 为了比较局部与口服类固醇在改善视力敏度方面的疗效.
- 为了确定类固醇开始的时间是否会影响治疗结果.
主要方法:
- 对9名被诊断患有眼球梅毒的男性患者 (18只眼睛) 的回顾性分析.
- 所有患者都接受了青素与局部或口服类固醇相结合.
- 视力敏度 (logMAR) 和裂纹灯的发现在多个后续点进行了评估.
主要成果:
- 与局部类固醇组相比,口服类固醇组在短期和长期随访中显示出明显更好的视力敏度.
- 口服类固醇组与局部组不同,从基线显示出显著的视觉改善.
- 与青素同时开始使用类固醇并没有比延迟启动产生更好的视觉结果.
结论:
- 类固醇是眼球梅毒的有效辅助疗法.
- 口服类固醇在增强视觉功能方面似乎比局部类固醇更有效,特别是在严重的炎症中.
- 与青素相比,类固醇的服用时间不会显著改变视力敏度的结果.
相关概念视频
Open Angle Glaucoma: Treatment
479
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
479
Angle Closure Glaucoma: Treatment
560
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
560
Glaucoma: Overview
621
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
621
Sexually Transmitted Infections
349
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
349


