一位患有慢性骨髓单细胞白血病的患者对5-azacitidine的异常反应
1Division of Hematology/Oncology, Department of Medicine Buffalo General Hospital Buffalo General Medical Center Buffalo New York USA.
Clinical case reports
|August 7, 2023
概括
像5-azacitidine (AZA) 这样的低甲基化剂可以治疗慢性骨髓单细胞白血病 (CMML). 然而,一些CMML患者可能没有反应,可能会出现疾病进展,正如本病例报告所示.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 慢性骨髓单细胞白血病 (CMML) 是一种罕见的,异质的血液癌症,通常在老年人中发现.
- 它与骨髓质疏松症候群 (MDS) 和骨髓增殖性新生瘤 (MPN) 有共同的特征,具有转化为急性骨髓性白血病的风险.
- 经FDA批准的低甲基化剂 (HMA),包括5-azacitidine (AZA) 和decitabine (DEC),用于治疗CMML.
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