干牛治疗对乳腺炎病原体产卵后抗菌耐药性的影响
Emmanuel Okello1,2, Wagdy R ElAshmawy1,3, Deniece R Williams1
1Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United States.
Frontiers in veterinary science
|August 7, 2023
概括
干牛疗法 (DCT) 对产后乳腺炎病原体的抗菌素耐药性 (AMR) 有影响. 干旱期间的乳腺内抗菌药物 (AMD) 管理与凝固酶阴性葡萄球菌种的AMR增加有关.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 动物科学 动物科学
背景情况:
- 抗菌素耐药性 (AMR) 在牛乳腺炎中越来越令人担忧.
- 干牛疗法 (DCT) 是一种常见的做法,用于在干旱期间管理乳腺炎.
- 了解DCT对AMR概况的影响对于负责任的抗微生物药物使用至关重要.
研究的目的:
- 评估DCT对乳腺炎病原体产卵后AMR概况的影响.
- 为了研究抗菌药物治疗 (AMD) 在干燥和AMR表型之间的关联.
- 确定特定的AMD和与AMR增加相关的病原体类型.
主要方法:
- 使用了DCT试验的分离物,包括来自382头母牛的566个分离物.
- 在干燥 (S1),产后 (S2) 和临床乳腺炎 (S3) 期间采集的牛奶样本.
- 使用微稀释确定了AMR概况,并分析了与回归模型的关联.
主要成果:
- 凝聚酶阴性葡萄球菌 (CNS) 隔离物在接受DCT的奶牛中显示出产后对青素的耐药性增加.
- 中枢神经系统分离物中对四环环素的耐药性与干燥时的任何AMD治疗有关.
- 当DCT使用相同或相关类别的药物时,中枢神经系统分离物中对洛丁,西林和西的耐药性增加.
结论:
- 干牛乳内抗菌药物 (AMD) 的使用与产后AMR有关.
- 在DCT中使用的特定AMD类可以影响乳腺炎病原体的AMR概况.
- 需要进一步的研究来优化DCT协议以减轻AMR的发展.
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