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Updated: Jul 19, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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乳腺癌:朝着对不可治愈癌症的现实性小鼠模型迈进

Maria Pérez-Lanzón1,2, Maria Chiara Maiuri1,2,3, Carlos Lopez-Otin4

  • 1Centre de Recherche des Cordeliers, Équipe Labellisée Par la Ligue Contre le Cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.

Oncoimmunology
|August 7, 2023
PubMed
概括

研究人员开发了一种新的激素受体阳性乳腺癌 (BC) 细胞系. 这种BC模型逃脱了免疫监测,导致小鼠在治疗上无法控制的瘤.

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Mouse Models of Cancer Study02:43

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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