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相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

1.8K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.8K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

1.9K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
1.9K
Synteny and Evolution02:31

Synteny and Evolution

3.3K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.3K
Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

1.8K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
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相关实验视频

Updated: Jul 19, 2025

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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洞穴:Connectome的注释版本引擎

Sven Dorkenwald1,2, Casey M Schneider-Mizell3, Derrick Brittain3

  • 1Princeton Neuroscience Institute, Princeton University, Princeton, USA.

bioRxiv : the preprint server for biology
|August 7, 2023
PubMed
概括
此摘要是机器生成的。

连接组注释版本引擎 (CAVE) 允许在持续的注释和校对过程中立即,可重复分析大规模的连接组数据集. 该基础设施支持用于特级大脑绘图项目的持续版本和快速数据查询.

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科学领域:

  • 神经科学是一个神经科学.
  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 由于电子显微镜和计算基础设施的进步,大规模的连接原子数据集正在增长.
  • 这些数据集的共享和协作注释对于神经科学研究至关重要.
  • 同时注释和错误校正 (校对) 对于大规模数据集中准确的细胞身份标记是必要的.

研究的目的:

  • 将Connectome注释版本引擎 (CAVE) 作为一个计算基础设施.
  • 为了在特级数据集上实现即时和可重复的连接组分析.
  • 支持正在进行的校对和注释过程.

主要方法:

  • CAVE提供了一个分布式基础设施,用于连续版本的大型神经元重建.
  • 标注是位置定义的,允许快速分配到底层部分以进行高效的分析.
  • 该系统支持用于各种研究需求的图表化和可扩展的注释.

主要成果:

  • 凯夫 (CAVE) 便于对特级连接原子数据集进行即时和可重复的分析.
  • 它允许并发校对和注释,管理数百万个voxel重新标记和数千个注释.
  • 快速分析查询可以在不断变化的数据集的任意时间点进行.

结论:

  • CAVE提供了一个强大的解决方案,用于管理和分析大型,动态的连接数据.
  • 它通过提供版本访问不断更新的神经元重建来支持协作研究.
  • 该基础设施具有可扩展性,并且已经用于一些可用的最大的connectomics数据集.