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Updated: Jul 19, 2025

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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致病性LRRK2对RAB3的酸化损害了突触囊泡前体的贩运

Dan Dou1,2,3, Jayne Aiken1, Erika L F Holzbaur1,2,3

  • 1Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

bioRxiv : the preprint server for biology
|August 7, 2023
PubMed
概括

致病性LRRK2突变通过改变RAB3A酸化来破坏帕金森病中的轴突运输. 这会损害突触囊泡的传递,导致神经元功能障碍和疾病症状.

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