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Updated: Jul 31, 2026

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
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利用Qubevirus平台绘制SARS-CoV尖端蛋白的免疫学和宿主受体结合决定因素

Carrie Sanders, Aristide Dzelamonyuy, Augustin Ntemafack

    bioRxiv : the preprint server for biology
    |August 7, 2023
    PubMed
    概括

    研究人员使用Qubevirus平台绘制SARS-CoV尖端 (S) 蛋白质表位图. 他们确定了ACE2和抗体标的关键结合部位,有助于开发疫苗和生物制剂.

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    Conjugated Proteins

    Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
    Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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    Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...