腹部海马体中的多巴胺感应D1和D2神经元在焦虑中仲裁接近和避免焦虑
Arthur Godino1, Marine Salery1, Angelica M Minier-Toribio1
1Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
bioRxiv : the preprint server for biology
|August 7, 2023
概括
腹部海马体中的多巴胺受体神经元在焦虑期间协调接近-避免决策. 不同的多巴胺受体类型调解相反的行为,揭示多巴胺.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 海马和多巴胺回路对于在引发焦虑的情况下做出决策至关重要.
- 多巴胺在调节海马体对情绪刺激的表现以解决冲突方面所起的确切作用仍然不清楚.
研究的目的:
- 研究多巴胺如何调节表腹海马 (vHipp) 中表达多巴胺D1或D2受体的神经元.
- 阐明这些神经元群体在焦虑时调解接近与避免行为中的独特作用.
主要方法:
- 在小鼠vHipp中对多巴胺感受神经元的转录概况和地形绘制.
- 在焦虑性探索期间的体内电生理学记录和行为分析.
- 探讨在腹部体内神经元活动和行为的多巴胺基调节.
主要成果:
- 在vHipp中的多巴胺D1和D2受体神经元在转录和地形上是不同的.
- 这两种神经元类型都在腹部垂体中在焦虑性探索期间被招募,具有差异性配置.
- 这些神经元群体介导对立的接近和避免反应,并由多巴胺差异调节.
结论:
- 腹部海马体多巴胺动力学对于在上下文不确定性中封锁探索性行为至关重要.
- 在vHipp中,多巴胺感受神经元在解决方法避免冲突方面发挥着关键作用.
- 这意味着多巴胺受体在情绪状态调节的基础上的神经计算.
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