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Updated: Jul 19, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

下一条流管道为Visium和H&E数据从患者衍生的异种移植样本

Sergii Domanskyi, Anuj Srivastava, Jessica Kaster

bioRxiv : the preprint server for biology

|August 7, 2023

概括

我们创建了一个自动化管道来分析来自患者的异种移植的空间转录和H&E图像. 该工具整合了基因表达和成像数据,揭示了类似的生物模式,以加强癌症研究.

科学领域:

计算生物学计算生物学
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

空间转录和组织学成像对于理解组织结构和基因表达至关重要.
分析患者衍生异种移植 (PDX) 模型需要强大的方法来区分宿主和移植数据.
整合来自空间转录组学和血素和乙素 (H&E) 成像的多模式数据带来了分析挑战.

结论:

开发的管道提供了一个可扩展,便携和用户友好的框架,用于集成的空间转录和H&E图像分析.
证明了管道在黑色素瘤PDX样本上的实用性,显示了空间基因表达和H&E成像特征之间的一致集群模式.
这种方法促进了多模式比较,提高了对瘤微环境和PDX模型的理解.

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A Patient-Derived Xenograft Model for Venous Malformation

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Published on: June 15, 2020

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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...