在Citrobacter rodentium肠道感染期间,TRPV1控制天生的免疫力
Michael Cremin1, Emmy Tay1, Valerie T Ramirez1
1Department of Anatomy, Physiology and Cell Biology, UC Davis School of Veterinary Medicine, UC Davis, Davis, California, USA.
bioRxiv : the preprint server for biology
|August 7, 2023
概括
暂时受体潜在化物受体1 (TRPV1) 通道对于对肠道病原体的宿主防御至关重要. TRPV1淘汰的小鼠表现出增加的细菌负担和炎症,突出了TRPV1的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 粘膜免疫能保护肠道病原体,但需要严格监管以防止免疫病理.
- 神经元通信,特别是通过表达过渡受体潜在化受体1 (TRPV1) 离子通道的专门感觉神经元,在协调宿主对细菌病原体的保护性反应中发挥着关键作用.
结论:
- TRPV1在协调宿主对肠道细菌病原体的保护性反应方面发挥着至关重要的作用.
- 在肠道感染期间,TRPV1通道对于调节先天性免疫细胞招募,特别是中性粒细胞,至关重要.
- 这些发现强调了TRPV1在维持粘膜体免疫平衡和对病原体的防御方面的重要性.
相关概念视频
01:11Enteric Nervous System: Regulation of GI Motor Activity
458
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
458
01:16Transduction
42
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
42