相关实验视频
Updated: Jul 19, 2025

07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
4.1K
肠道微生物组和与代谢相关的脂肪肝疾病:目前的状况和潜在的应用
Gong-Jing Guo1, Fei Yao2, Wei-Peng Lu3
1Gastroenterology Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen 518172, Guangdong Province, China.
World journal of hepatology
|August 7, 2023
概括
与代谢相关的脂肪肝疾病 (MAFLD) 越来越常见. 肠道微生物群 (GM) 的变化显著影响MAFLD的发展和通过肠肝轴的进展.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 代谢疾病 代谢疾病
背景情况:
- 代谢相关脂肪肝 (MAFLD) 是一个普遍的全球健康问题,由现代生活方式和饮食习惯驱动.
- 肠道微生物群 (GM) 在宿主新陈代谢,免疫和营养合成中起着至关重要的作用.
- 肠肝轴,一种双向通信通道,越来越多地被认为在肝脏疾病的发病过程中的作用.
研究的目的:
- 审查当前对MAFLD肠道微生物群变化的理解.
- 探索将肠道微生物群与MAFLD联系在一起的机制,包括胆酸循环,能量代谢和信号通路.
- 总结针对肠道微生物群的新兴MAFLD治疗策略.
主要方法:
- 关于研究MAFLD的肠道微生物群的文献综述.
- 对包括16S测序在内的多omics数据的分析,以对MAFLD患者的GM进行表征.
- 在肠肝轴的背景下讨论转基因及其代谢物的功能作用.
主要成果:
- MAFLD与肠道微生物群组成和功能的明显变化有关.
- 肠道微生物群失生症通过改变胆酸代谢,能量收获和炎症,促进MAFLD的发病.
- 肠肝轴是这些相互作用的关键调解器.
结论:
- 肠道微生物群失调是MAFLD发展和进展的重要因素.
- 准肠道微生物群为MAFLD提供了有前途的治疗途径.
- 对肠肝轴的进一步研究对于有效的MAFLD管理至关重要.
相关概念视频
Overview of Fatty Acid Metabolism
30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
Lipid Catabolism
57
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
57
Ultrasound II: Endoscopic Ultrasound and FibroScan
139
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
139
What is Monogastric Digestion?
71.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.5K

