中国中风遗传倾向与疾病负担之间的关联:一项遗传流行病学研究
Qiya Huang1, Xianmei Lan2,3, Hebing Chen4
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The Lancet regional health. Western Pacific
|August 7, 2023
概括
对中风的遗传倾向显示了中国的南北梯度,影响了死亡率和残疾等疾病负担. 这种遗传风险独立地为中风相关的健康影响贡献了1-6%.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在全球和中国,中风是导致死亡和残疾的主要原因.
- 脑卒中具有复杂的多基因结构,受到环境和生活方式因素的影响.
- 对中风的遗传倾向与其疾病负担之间的关联仍然不清楚.
研究的目的:
- 为了估计中国中风的省级遗传倾向.
- 评估遗传倾向与中风的流行病学负担之间的关联.
- 量化遗传风险对中风死亡率和残疾的影响.
主要方法:
- 利用来自中国百万基数据库 (141,418个人) 的全基因组测序数据.
- 应用多基因风险评分模型来估计中国各省的遗传倾向.
- 从全球疾病负担研究中收集的疾病负担数据 (死亡率,DALYs,YLLs,YLDs,流行率).
- 使用回归和机器学习模型来分析省级协会.
主要成果:
- 在中国30个行政区 (p < 0.0001) 观察到,中风遗传倾向的北高于南显著的梯度.
- 发现了对中风的遗传倾向和血压,BMI和酒精使用 (rho > 0.6) 等风险因素之间的强烈相关性.
- 遗传风险独立地占中风死亡率,DALYs和YLLs变化的约1-6%.
结论:
- 脑卒中遗传倾向在中国呈现出明显的地理分布模式.
- 遗传倾向微妙但显著地影响了中风的流行病学负担.
- 需要进一步的研究来阐明详细的病因学,并将研究结果转化为公共卫生战略.
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