成为一个早晨的人对大脑皮质有因果作用:孟德尔的随机化研究
Fan Yang1,2,3,4,5, Ru Liu1, Sheng He1,6
1Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Province, China.
Frontiers in neuroscience
|August 7, 2023
概括
循环节律会影响大脑皮层结构,特别是减少面状中额头的表面积. 这一发现表明了有关神经系统疾病的潜在新诊断和治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 时间生物学 时间生物学
背景情况:
- 现有的研究将昼夜节律障碍与影响认知和意识的神经系统障碍联系起来.
- 然而,连接昼夜节律与特定大脑皮层结构的直接因果证据仍然有限.
研究的目的:
- 调查早晨 (衡量昼夜偏好) 与大脑皮层表面积 (SA) 和厚度 (TH) 之间的因果关系.
- 为了确定可能受到昼夜节律变化影响的特定大脑区域.
主要方法:
- 使用的全基因组关联研究 (GWAS) 对与早晨相关的单核酸多态度的总结统计.
- 采用孟德尔随机化 (MR) 分析,包括反变量加权 (IVW) 和加权中位数 (WM) 方法.
- 通过使用MR-Egger,MR-PRESSO,留下一个漏洞分析和漏斗图表来评估异质性和性.
主要成果:
- 清晨性与面积 (SA) 降低在正面中额回路的因果关系.
- 这种效应在基因组控制和没有基因组控制的情况下都被观察到,具有统计学上显著的p值.
- 没有发现显著的异质性或异常值,这支持了研究结果的稳定性.
结论:
- 昼夜节律,特别是早晨,因果关系地影响着面状中额头的表面积.
- 这就建立了昼夜节律和大脑皮层结构之间的直接联系.
- 结果可能会为基于MRI的疾病诊断,疾病进展的理解和相关神经系统疾病的新疗法策略提供信息.
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