心血管测量显示了强大的表型稳定性,跨越了长时间的间隔,涉及重复的睡眠剥夺和恢复
Lauren N Pasetes1, Kathleen M Rosendahl-Garcia2, Namni Goel1
1Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States.
Frontiers in neuroscience
|August 7, 2023
概括
心血管测量显示稳定,特征性反应重复的总睡眠剥夺 (TSD) 和恢复,作为可靠的生物标志物跨越长时间.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 生理学 生理学 生理学
背景情况:
- 心血管 (CV) 健康至关重要,但慢性睡眠障碍对心血管特征稳定性的影响尚不清楚.
- 了解对总睡眠不足 (TSD) 的特征性心血管反应对于评估长期健康影响至关重要.
研究的目的:
- 为了确定心血管测量是否在重复暴露于总睡眠剥夺 (TSD),基线 (BL) 和恢复 (REC) 期间表现出稳定,类似特征的反应.
- 评估CV测量作为生物标志物在长时间和重复睡眠操纵协议中的一致性.
主要方法:
- 两项涉及健康成年人的长期研究,在4个月和8个月的时间里,进行了TSD,BL和REC的重复实验协议.
- 坐着和站着的心血管测量,包括中风体积 (SV),心率 (HR),心脏指数 (CI) 和缩血压 (SBP),使用心声回声和血压监测器收集.
- 使用类内相关系数 (ICC) 和斯皮尔曼的rho来评估CV测量的稳定性和一致性.
主要成果:
- 坐着的CV测量显示,在8个月的时间内,在重复BL,TSD和REC暴露中,其稳定性很大,几乎是完美的 (ICCs为0.552-0.965).
- 在所有实验条件下,个人在坐着的CV测量中显示出显著和一致的反应.
- 与坐着测量相比,站立的CV测量显示出类似的稳定性和响应一致性.
结论:
- 这项研究为健康成年人接受重复TSD,BL和REC的多次CV测量提供了第一个强大的表型稳定性的证据.
- 像SV,HR,CI,LVET,SVRI和SBP这样的CV测量被验证为可靠的生物标志物,用于持续跟踪长时间睡眠剥夺和恢复期间的生理反应.
关键词:
心血管疾病的心血管疾病超声心电图 (Echocardiography) 是一种心声回声仪.血液动力学 血液动力学个人差异是个人的差异.类内相关系数的相关系数.现象型 现象型 是一种现象型.收回回收回收的恢复睡眠不足是因为睡眠不足.更多相关视频
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