延迟初级关闭的实践审查:基础科学和临床应用

相关实验视频

Updated: Jul 19, 2025

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

51.3K

Hassan ElHawary¹, Jason Covone², Shafic Abdulkarim³

¹From the Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montréal, Quebec, Canada.

Plastic and reconstructive surgery. Global open

|August 7, 2023

概括

延迟初级关闭 (DPC) 通过改善氧化和强度来增强伤口愈合,特别是对于受污染的伤口. 这种技术涉及几天后的机械关闭,建议用于特定的手术部位,以减少感染率.

科学领域:

手术创新在外科创新.
伤口愈合生理学伤口愈合生理学
基于证据的医学基于证据的医学.

背景情况:

伤口愈合并发症带来了巨大的负担.
延迟初级关闭 (DPC) 缺乏关于定义,征兆和结果的明确共识.
了解伤口愈合原理对于缓解并发症至关重要.

研究的目的:

审查伤口愈合的基础,专注于DPC.
检查DPC的执行,指示和比较结果.
为DPC提供基于证据的方法.

主要方法:

对DPC研究进行了PubMed文献搜索.
包括对DPC结果和并发症的比较研究.
包括研究DPC潜在生理学的文章.

主要成果:

DPC伤口表现出更高的氧气部分压力,血流,原合成和重塑.
这些因素有助于DPC伤口的优越机械强度.
在受污染的伤口 (例如尾切除术,心脏术后,腹壁重建) 中,DPC有益,减少手术部位感染.

结论:

推DPC用于受污染的腹部手术和心脏手术后的胸部伤口脱离.
DPC伤口应用盐水/贝塔丁水,每天灌.
延迟关闭应发生在3-5天之间或感染消失后.

相关概念视频

01:28

Phases of Wound Repair

6.1K

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...