生物阻抗:用于查口腔癌的工具 - - 系统性审查
Vaibhav Gupta1, Usha Agrawal1, Poonam Goel1
1CRIB Lab, National Institute of Pathology - ICMR, Delhi, India.
Contemporary clinical dentistry
|August 7, 2023
概括
生物阻抗光谱学 (BIS) 在检测口腔癌和癌前疾病方面表现有前途. 这种非侵入性,便携式技术可以区分正常和癌症口腔组织,有助于早期检测和社区查.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 有效的癌症管理依赖于通过查早期检测.
- 生物阻抗光谱 (BIS) 是检测乳腺癌,宫癌和前列腺癌的验证方法.
研究的目的:
- 系统地审查有关生物阻抗在诊断口腔状细胞癌 (OSCC) 的临床应用现有证据.
- 评估生物阻抗在检测口腔潜在恶性疾病 (OPMDs) 的实用性.
主要方法:
- 系统性审查遵循系统性审查和元分析 (PRISMA) 准则的首选报告项目.
- 搜索了主要数据库 (PubMed,MEDLINE,Embase,EBSCOhost,Google Scholar) 的英语文学作品,截至2022年3月.
- 包括的研究集中在人类参与者和BIS在查口腔癌前和癌症病变中的应用,以正常与癌症组织的差异化为主要终点.
主要成果:
- 确定了6754篇文章,其中481篇有资格被纳入,并最终确定了符合标准的五项研究.
- 在所有包括的研究中,定性分析显示了癌症和正常口腔组织在20 Hz和50 KHz之间的BIS指标的显著差异.
结论:
- 生物阻抗光谱显示出作为检测口腔癌的新工具的潜力.
- 它的非侵入性和可移植性使BIS适合于口腔恶性瘤的社区查计划.
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