先进的糖化最终产品信号和代谢并发症:饮食方法
Mohammad Idreesh Khan1, Fauzia Ashfaq2, Abdulrahman A Alsayegh2
1Department of Clinical Nutrition, College of Applied Health Sciences in Ar Rass, Qassim University, Ar Rass 51921, Saudi Arabia.
World journal of diabetes
|August 7, 2023
概括
先进的糖化终产品 (AGEs) 是热处理食品中发现的有害化合物. 饮食中的AGE会导致糖尿病和心血管疾病等慢性疾病,影响衰老和炎症.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 病理生理学 病理生理学
背景情况:
- 先进的糖化最终产品 (AGEs) 是通过加工和制食品中的非酶反应形成的.
- 西方饮食,富含加工谷物,炸肉和坚果等热处理物品,对饮食中的AGE摄入量有很大贡献.
- AGEs与衰老,代谢疾病和炎症状况有关.
研究的目的:
- 审查高级糖化最终产品 (AGEs) 的饮食来源.
- 要总结与AGE相关的代谢相关的并发症.
- 突出AGE在慢性疾病和生理衰老中的作用.
主要方法:
- 关于饮食中AGE及其对健康的影响研究的文献综述.
- 在各种食品加工方法 (炸,烧烤,,沸) 中分析AGE含量.
- 检查AGE在代谢疾病,心血管并发症和炎症途径中的作用.
主要成果:
- 经过高温处理的食物,如炸肉,培根和加工谷物,是AGE的重要来源.
- 在热处理动物蛋白和加工植物食品中发现高度的AGE,包括氨酸和碳甲氨酸.
- 血AGE水平增加与糖尿病,心血管疾病死亡率,心脏功能障碍和炎症性类风湿性疾病有关.
结论:
- 从加工和热处理食品中摄入高级糖化终产品 (AGEs) 的饮食是导致慢性疾病的重要因素.
- AGEs在糖尿病的病理生理学,心血管并发症和衰老中发挥着关键作用.
- 需要进一步的研究,以充分阐明将AGE与各种健康问题联系在一起的复杂机制.
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