糖化血红素A1c,尿中的微专蛋白,尿中的肌素,β2微球蛋白,视网醇结合蛋白和糖尿病视网膜病变之间的相关性
Jia-Jia Song1, Xiao-Fang Han2, Jian-Feng Chen2
1Department of Endocrinology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, China. sjj1832613@126.com.
World journal of diabetes
|August 7, 2023
概括
通过监测糖化血红蛋白A1c (HbA1c),尿液微专蛋白 (U-mALB),尿液肌素 (U-CR) 和其他生物标志物,可以改善糖尿病视网膜病变 (DR) 查. 将这些标记物结合在一起,可以在预测DR进展方面提供高准确度.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 糖尿病视网膜病变 (DR) 是2型糖尿病的主要微血管并发症,在早期往往无症状.
- 早期检测和干预对于管理DR和预防视力丧失至关重要.
- 确定用于DR查的可靠生物标志物对于及时诊断和治疗至关重要.
研究的目的:
- 调查关键生物标志物与糖尿病视网膜病变 (DR) 的存在和严重程度之间的相关性.
- 为了评估血糖血红蛋白A1c (HbA1c),尿液微蛋白 (U-mALB),尿液肌素 (U-CR),mALB/U-CR比率,β2微球蛋白 (β2MG) 和视网结合蛋白 (RBP) 的预测值,对DR.
- 确定与DR的发展和进展相关的风险因素.
主要方法:
- 对180名2型糖尿病患者的回顾性分析,分为非视网膜病变 (NDR),非增殖性DR (NPDR) 和增殖性DR (PDR) 组.
- 收集的数据包括人口统计,疾病持续时间以及HbA1c,U-mALB,U-CR,mALB/U-CR,β2MG和RBP的水平.
- 统计分析包括皮尔森的相关性,多重线性回归和接收器操作员特征 (ROC) 曲线分析.
主要成果:
- 疾病持续时间,HbA1c,U-mALB,U-CR,mALB/U-CR,β2MG和RBP被确定为DR的重要风险因素.
- 与NPDR和NDR组相比,PDR组患者的HbA1c,U-mALB,U-CR,mALB/U-CR,β2MG和RBP水平较高.
- 使用所有六种生物标志物的组合模型实现了0.958的AUC,具有PDR预测的高灵敏度 (94.83%) 和特异性 (96.72%).
结论:
- HbA1c,U-mALB,U-CR,mALB/U-CR,β2MG和RBP是反映DR发展和进展的有价值的指标.
- 这些生物标志物是增殖性糖尿病视网膜病变 (PDR) 的重要危险因素.
- 这六种生物标志物的组合显示了PDR的强有力的预测价值.
相关概念视频
Urine Studies I: Urinalysis
40
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
40
Serum Studies: Renal Function Tests
23
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
23
Renal Corpuscle
2.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.6K
Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
Diabetes: Symptoms, Diagnosis, and Complications
590
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
590


