血小板与淋巴细胞的比率作为初级高血压中间接结果预测因素:一项回顾性研究
Rita Pinho1, Rui Ribeiro1, Diana Ferrão1
1Department of Medicine, Centro Hospitalar de São João, Porto, Portugal.
Porto biomedical journal
|August 7, 2023
概括
非滴滴高血压与较高的血小板-淋巴细胞比率和心血管风险增加有关. 这种炎症标记可能有助于预测高血压患者的心血管事件.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 炎症生物标志物 炎症生物标志物
背景情况:
- 非滴水高血压与血小板与淋巴细胞比率 (PLR) 的升高有关,这是一个炎症生物标志物.
- 高血压模式,特别是非滴水状态,与心血管发病率和死亡率的增加相关.
- 了解PLR,高血压模式和心血管事件之间的关系对于风险分层至关重要.
研究的目的:
- 调查血小板与淋巴细胞的比率和高血压模式 (滴水器与非滴水器) 之间的关联.
- 检查高血压模式与主要心血管不良事件发生之间的关系.
- 评估PLR作为初级高血压中心血管风险的间接预测因素的潜力.
主要方法:
- 对153名初级高血压患者的回顾性分析.
- 根据24小时的门诊血压监测,将患者分为滴水和非滴水组.
- 从完整血清数据计算血小板与淋巴细胞的比率.
主要成果:
- 与Dipper患者相比,非Dipper患者 (44) 的血小板与淋巴细胞比率显著更高 (109) (OR = 2.11;P = .007).
- 没有滴水高血压的个体早些时候经历了主要的不良心血管事件,包括心肌梗塞和中风 (P < .001).
结论:
- 非浸泡型高血压患者表现出血小板与淋巴细胞的比率升高,早期心血管事件的发病率更高.
- 血小板与淋巴细胞的比率可以作为一个有价值的间接生物标志物,用于预测初级高血压中心血管风险.
- 识别非浸泡状态和升高的PLR可以帮助优化心血管疾病的预防策略.
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