在选择性THR或TKR后,使用埃诺沙巴林进行有效的VTE预防:一项回顾性观察性研究
Diogo Nóbrega Catelas1,2, Filipa Cordeiro1,2, Luís Loureiro3
1Department of Orthopedic Surgery, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
Porto biomedical journal
|August 7, 2023
概括
接受关节或膝关节置换 (THR/TKR) 的整形外科患者在使用埃诺沙巴林预防时表现出较低的静脉血栓栓塞 (VTE) 率. 在这项研究中,高度遵守VTE预防导致VTE事件最小.
科学领域:
- 整形外科 整形外科 整形外科
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨科患者面临着静脉血栓栓塞 (VTE) 的最高风险.
- 常规VTE预防可显著降低致命的肺栓塞 (PE) 和全置换 (THR) 和全膝置换 (TKR) 后的症状性VTE病率.
- 在THR/TKR患者中,预预防VTE的发病率高达50%-70%.
研究的目的:
- 评估VTE预防在接受THR和TKR的患者中的有效性.
- 评估在THR/TKR后用埃诺沙巴林治疗的患者中VTE的发生率.
- 在圣安东尼奥大学医院中心 (CHUdSA) 分析VTE预防实践.
主要方法:
- 这是一项从2019年3月至2020年2月接受选用THR或TKR的483名患者的回顾性研究.
- 埃诺沙巴林被用作所有被纳入患者的静脉瘤预防药物.
- 关于处方埃诺沙巴林持续时间的数据来自全国电子药物处方系统 (PEM).
主要成果:
- 这项研究包括192名THR患者 (39.75%) 和291名TKR患者 (60.25%).
- 埃诺沙巴林在THR的平均时间为31.86天,TKR的平均时间为30.28天.
- 静脉瘤发病率在THR组为3.13%,在TKR组为0.69%.
结论:
- 伊诺沙巴林40毫克每天服用一次,长达35天,是CHUdSA对THR/TKR的标准VTE预防方法.
- 较高的治疗合规率导致了静脉瘤事件的发病率较低.
- 实施的VTE预防策略在尽量减少VTE发生后的骨科手术中被证明是有效的.
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