通过各种多元组件晶体探索硫沙拉的晶体结构景观
Shan Huang1,2, Vinay K R Cheemarla1, Davide Tiana1
1School of Chemistry, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 K8AF, Ireland.
Crystal growth & design
|August 7, 2023
概括
通过使用晶和盐形成剂,创建了新的硫沙的多元固体. 这些新形式表现出一个关键的结构图案,并揭示了对硫素的洞察力.
科学领域:
- 固态化学 固态化学
- 晶体学 晶体学是指结晶学.
- 制药科学 制药科学 制药科学
背景情况:
- 硫沙拉是一种用于炎症性肠病和类风湿性关节炎的抗炎药物.
- 已知存在两种硫沙的固态复合体:胺基 (三临床) 和胺基 (单临床).
研究的目的:
- 为了合成和表征新的多组分固体形式的硫素.
- 为了研究硫素在同晶体和盐中的结构特征和复合体行为.
- 分析新的固体形式的分子间相互作用和化学稳定性.
主要方法:
- 使用了泥结晶,液体辅助研磨和缓慢蒸发技术.
- 描述涉及X射线衍射,热分析和里埃变换红外光谱学.
- 进行了晶体结构分析和希尔什菲尔德表面分析.
主要成果:
- 已经成功地结晶了六种新的多元固体 (三种共晶,三种盐) 的硫.
- 一个重复的结构动机,一个R2^2(7):R2^2(8):R2^2(7) 排列,在所有新形式和imide多态中都被确定.
- 苏尔法萨拉在未化晶体中采用了氨基酸体,在化共晶体和盐中采用了氨基酸体.
- 晶显示出显著的键供体能力,而盐则充当键受体.
- 与盐相比,晶显示出更大的化学稳定性.
结论:
- 成功制备了新的硫沙的多元固体,扩大了其固态景观.
- 已识别的结构图案对于各种固体形式的硫沙的组装至关重要.
- 陶托马体的行为受到溶解和共晶或盐形成物的存在的影响.
- 硫素的晶提供了更好的化学稳定性,这表明了潜在的治疗优势.
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