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Txnip表达促进JNK介导的神经元死亡,以应对活性氧物种

Brenda García-Hernández1, Julio Morán1

  • 1División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Frontiers in molecular neuroscience
|August 7, 2023
PubMed
概括

活性氧物种 (ROS) 通过FOXO3激活增加TXNIP表达,促进神经元死亡. 降低TXNIP的调节减少了这种细胞死亡,突出了TXNIP作为神经退行性疾病的治疗点.

关键词:
标签: 活动 活动 活动在FOXO3中使用FOXO3.这就是MAPKK的意思.铁素相互作用蛋白质灭症 (apoptosis) 是一种死亡的过程.小脑颗粒神经元的神经元有活性氧物种的反应性氧物种.

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