超快速作用的微针用于即时输送生物治疗药物
Jiahuan You1, Changwei Yang1, Jinpeng Han1
1Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Advanced materials (Deerfield Beach, Fla.)
|August 7, 2023
概括
这项研究引入了一种超快速作用的微针 (URA-MN) 贴片,用于快速,微创的通过皮肤递送药物. 乌拉-MN贴片能够在几分钟内快速释放生物治疗和强效,改善患者的服从性.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 皮下注射 (SC) 在生物治疗中很常见,但需要专业的帮助,导致疼痛和感染风险.
- 基于注射器的注射会对患者的遵守和生活质量产生负面影响.
- 需要使用最少入侵的,对患者友好的药物输送方法.
研究的目的:
- 开发和评估一种超快速作用的微针 (URA-MN) 贴片,可立即通过皮肤递送.
- 为了在几分钟内实现快速的生物治疗释放和治疗效果.
- 为了评估URA-MN贴片的生物相容性.
主要方法:
- 在URA-MN尖端中加入泡剂,在皮肤插入时产生CO2气泡.
- 评估从URA-MN贴片中释放利拉古 (LRT),胰岛素和肝素的释放动力学.
- 在三个不同的小鼠模型中,在六周内评估治疗效果和生物相容性.
主要成果:
- 在5分钟内,URA-MN贴片能够快速释放各种生物治疗药物.
- 强大的治疗效果是在短时间内获得的.
- 在六周后,URA-MN贴片显示出可取的生物相容性,其残留量可以忽略不计.
结论:
- 乌拉-MN贴片提供了一种新,高效和最少侵入性的方法,用于快速通过皮肤递送药物.
- 这项技术通过减少注射时间和增强患者体验,显著改善了传统的皮下注射.
- 乌拉-MN贴片对改善患者在生物治疗治疗中的遵从性和生活质量有希望.
相关概念视频
01:29Drug Delivery: Parenteral Route
618
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
618
01:25Routes of Drug Administration: Parenteral
2.0K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.0K
01:22Drug Delivery: Miscellaneous Routes
381
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
381
01:16Drug Delivery: Overview
322
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
322
01:22Routes of Drug Administration: Overview
6.3K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.3K
01:27Insulin Formulations: Types and Delivery
226
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
226