在异常性 dystonia 中加速计衍生睡眠测量:英国生物银行队列研究
Grace A Bailey1, Megan E Wadon1, Sandra Komarzynski2
1Neuroscience and Mental Health Research Institute, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Brain and behavior
|August 7, 2023
概括
患有 dystonia 的人的睡眠质量较差,昼夜节律发生改变,这是主观报告和客观加速度计数据所表明的. 这些睡眠障碍可能会影响整体的 dystonia 状态.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 生物医学工程 生物医学工程
背景情况:
- 睡眠障碍是 dystonia 的一个公认的非运动症状.
- 之前关于睡眠在 dystonia 的研究已经产生了各种各样的结果.
- 这项研究调查了英国生物银行 dystonia队列中的睡眠模式.
研究的目的:
- 为了比较 dystonia 患者和对照者之间的主观睡眠症状和客观睡眠测量.
- 评估加速度计对评估睡眠障碍在 dystonia 的实用性.
- 为了探索睡眠变化与 dystonia 的临床表型之间的关系.
主要方法:
- 将241例 dystonia 病例与964个匹配的对照进行了比较.
- 利用了主观的自我报告的睡眠数据.
- 采用手腕穿戴的三轴加速度计,用于客观的睡眠结构分析.
主要成果:
- 抑郁症参与者报告睡眠模式比对照组更差.
- 客观测量显示,在 dystonia 患者中,睡眠时间较晚,在床上时间减少,以及改变昼夜节律.
- 没有发现与疼痛有显著的关联;与精神病症状的联系有限.
结论:
- 加速度计是有效的长期睡眠评估和治疗响应监测在 dystonia.
- 改变睡眠和昼夜节律在 dystonia 患者中比对照患者更为普遍.
- 这些睡眠障碍可能会导致 dystonia 临床表型.
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