亚裔美国人群中多发性硬化和脱髓化疾病的特征
Jessica H Fan1,2, Jessa Alexander1, Shane Poole1
1Department of Neurology, UCSF Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.
Multiple sclerosis (Houndmills, Basingstoke, England)
|August 7, 2023
概括
患有多发性硬化症 (MS) 的亚裔美国患者的疾病严重程度与非亚裔患者相似. 然而,祖先影响了社会人口统计和多发性硬化症的结果,这需要进一步调查潜在因素.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 人种和祖先是影响多发性硬化症 (MS) 进展的已知因素.
- 了解这些影响对于个性化的患者护理和治疗策略至关重要.
- 亚裔美国人群体代表着一个具有独特健康考虑的多元化群体.
研究的目的:
- 在亚裔美国患者中调查MS和神经omyelitis optica光谱障碍 (NMOSD) 的临床特征.
- 为了将这些特征与非亚洲MS患者进行比较.
- 根据祖先的地区来探索亚裔美国人亚组中的变异.
主要方法:
- 在北美多发性硬化中心对282名患有脱髓化疾病的成年患者进行了回顾性图表审查.
- 患者自我认定为亚裔,他们的数据与非亚裔多发性硬化症患者进行了比较.
- 分析了人口统计和临床数据,并根据亚洲血统地区进行了子组分析.
主要成果:
- 亚洲MS患者的诊断年龄比非亚洲患者年轻.
- 多发性硬化症严重程度评分与非亚洲患者相似,但在东南亚亚裔亚组中更差.
- 神经omyelitis optica光谱障碍 (NMOSD) 在东亚和东南亚患者中更为普遍.
结论:
- 亚裔美国患者的多发性硬化症 (MS) 严重程度与非亚洲人群相似.
- 区域血统与亚裔美国人的社会人口结构和MS严重程度的变化有关.
- 进一步的研究对于阐明导致这些观察到的差异的遗传,社会经济和环境因素至关重要.
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