针对高体积转移性激素敏感前列腺癌的系统疗法:一个网络元分析
Zhonghan Zhou1, Shuai Liu1, Jingchang Mei1
1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Acta oncologica (Stockholm, Sweden)
|August 7, 2023
概括
三合一疗法,包括达罗胺或阿比拉特加多塞塔克塞尔和雄激素剥夺疗法 (ADT),为高体积转移性激素敏感前列腺癌 (mHSPC) 提供最好的整体存活率. 雷兹维胺加ADT是一种高度排名的双重疗法选择.
科学领域:
- 在瘤学瘤学.
- 医学科学 医学科学 医学科学
- 临床试验 临床试验
背景情况:
- 大量的转移性激素敏感前列腺癌 (mHSPC) 需要有效的全身疗法.
- 优化治疗方案对于改善患者治疗结果至关重要.
研究的目的:
- 为了比较高容量的mHSPC可用的全身疗法的有效性.
- 为了确定这个患者群体的最佳治疗策略.
主要方法:
- 在大批量mHSPC中对随机对照试验 (RCT) 进行了系统的文献搜索.
- 贝叶斯网络元分析被用来比较整体存活率 (OS) 和无进展存活率 (PFS).
主要成果:
- 三重疗法 (达洛胺+多塞塔克塞尔+ADT和阿比拉特+多塞塔克塞尔+ADT) 显示了最大的OS改善.
- 雷兹维胺+ADT是OS的排名最高的双重治疗,其次是三重治疗.
- 所有评估的疗法都改善了PFS;三重疗法排名最高,其次是恩扎胺和雷兹维胺.
结论:
- 三重治疗方案 (DAR+DOC+ADT和ABI+DOC+ADT) 在大量的mHSPC中提供了最显著的OS益处.
- 雷兹维胺+ADT是改善这一患者群体的OS的主要双重疗法选择.
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