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相关概念视频

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Biological Clocks and Seasonal Responses02:45

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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相关实验视频

Updated: Jul 19, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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在自身免疫性甲状腺炎中循环时钟的干扰.

Jinrong Fu1,2, Zihao Fan3, Liang He4

  • 1Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

European thyroid journal
|August 7, 2023
PubMed
概括

循环时钟的干扰会通过减少时钟基因表达和增加炎症来损害自身免疫性甲状腺炎 (AIT). 保持定期的昼夜节律可能有助于管理AIT.

关键词:
自免疫性甲状腺炎的发生.时钟中断 时间中断时钟基因的时间基因这是一种炎症炎症炎症炎症.

更多相关视频

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
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相关实验视频

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科学领域:

  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.
  • 时间生物学 时间生物学

背景情况:

  • 在炎症性疾病中,昼夜干扰与增强的免疫反应之间存在联系.
  • 生物钟在自身免疫性甲状腺炎 (AIT) 中的破坏作用需要进一步研究.

研究的目的:

  • 探索昼夜时钟中断对自身免疫性甲状腺炎的影响.
  • 评估AIT中的时钟基因表达和炎症标志物之间的关系.

主要方法:

  • 来自AIT患者和对照组的甲状腺组织被分析为核心时钟基因表达和炎症生物标志物.
  • 实验性自身免疫甲状腺炎 (EAT) 在小鼠中被诱导,以研究昼夜特征和光转移 (LS) 对EAT的影响.

主要成果:

  • 在AIT甲状腺组织中观察到BMAL1和PER2时钟基因的减少表达,与甲状腺过氧化酶抗体相关.
  • EAT小鼠模型显示,炎症性细胞因子的日间波动;LS条件加剧了TNF-α,IFN-γ和抗铁血球蛋白抗体的产生.
  • 多个时钟基因 (Bmal1,Clock,Per2,Cry1,Ror,Rev-erb) 的显著振荡在EAT,LS和组合EAT+LS条件下受到干扰.

结论:

  • 时钟基因表达模式在甲状腺中被破坏.
  • 慢性昼夜干扰可能会加剧AIT的炎症反应.
  • 需要进一步的研究来确定定期的昼夜节律是否可以缓解自身免疫性甲状腺疾病.