结直肠癌的衰老特征基于肠道微生物群
Yinhang Wu1,2,3, Jing Zhuang1,2,3, Qi Zhang1
1Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, China.
Cancer medicine
|August 7, 2023
概括
老龄化影响肠道微生物群组成,影响结直肠癌 (CRC) 风险. 与年龄相关的肠道细菌可以预测CRC,强调在基于微生物群的风险评估中需要考虑年龄.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 老年学是一门学科.
背景情况:
- 老龄化是癌症发展的重要危险因素.
- 肠道微生物群在衰老过程和结直肠癌 (CRC) 发病过程中起着至关重要的作用.
研究的目的:
- 研究肠道微生物群组成,衰老和结直肠癌之间的关系.
- 根据肠道细菌概况,开发年龄和CRC风险的预测模型.
主要方法:
- 分析了11个元基因组CRC数据集,按年龄分层样本.
- 利用LEfSe和Spearman相关性来识别健康和CRC个体中的年龄差异化细菌.
- 使用机器学习构建的年龄和CRC风险预测模型.
主要成果:
- 肠道微生物群的结构在各个年龄组之间有显著差异,特定的细菌,如细菌菌 (Bacteroides fragilis),随着年龄的增长而增加.
- 在CRC患者中,病原性细菌的数量随着年龄的增长而增加,而益生菌的数量则减少.
- 为年龄 (AUC=0.79) 和CRC风险 (AUC=0.83) 开发了准确的预测模型,年龄特定的模型显示出高性能.
结论:
- 肠道微生物群的组成因衰老而显著改变,并与结直肠癌有关.
- 与年龄相关的细菌变化对于准确的CRC风险预测至关重要.
- 将年龄纳入肠道微生物群分析对于有效的CRC风险评估至关重要.
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