肠道微生物群预测COVID-19的严重程度和死亡率,无论医院的养方法如何
Vanni Bucci1,2,3, Doyle V Ward1,2,3, Shakti Bhattarai1,2,3
1Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School , Worcester, Massachusetts, USA.
mSystems
|August 7, 2023
概括
肠道微生物组,而不是口腔微生物组,准确地预测了住院患者的COVID-19严重程度和死亡率. 医院养方法没有影响严重COVID-19疾病的预测性肠道微生物物种.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 计算生物学 计算生物学
背景情况:
- SARS-CoV-2 感染与肠道和口腔微生物组失调有关.
- 微生物组的改变与COVID-19疾病的严重程度和结果相关.
- 了解这些关联对于预测患者的预后至关重要.
研究的目的:
- 识别肠道和口腔微生物群标记物,用于预测住院患者的COVID-19严重程度.
- 将肠道微生物群与口腔微生物群的预测值进行比较,以确定COVID-19的死亡率和严重程度.
- 研究医院养 (肠道与固体) 对肠道微生物组成的影响.
主要方法:
- 使用随机森林分类机器学习模型.
- 使用可解释的二次分析来识别微生物标记物.
- 将微生物预测因子与已确定的临床变量进行比较.
主要成果:
- 肠道微生物群在住院患者中强有力的预测了COVID-19死亡率和严重程度.
- 口腔微生物群对COVID-19严重程度的预测价值有限.
- 肠道养引起的肠道微生物干扰与严重性预测物种没有相关性.
结论:
- 肠道微生物组组成是严重COVID-19结果的重要预测因素.
- 与临床变量相比,基于微生物组的标记物可能提供更好的预测.
- 这些发现突出了微生物组在COVID-19病变发生过程中的作用,并为潜在的治疗策略提供了信息.
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