莱特莫维尔用于小儿血造干细胞移植中的细胞巨乳病毒预防
Teaghan T Chen1, Alexandria P David1, Erin K Barthelmess1
1Department of Pharmacy, Children's Hospital Colorado, Aurora, Colorado, USA.
Pediatric blood & cancer
|August 7, 2023
概括
莱特莫维尔 (LTV) 预防在小儿血液细胞移植 (HCT) 患者的细胞巨乳病毒 (CMV) DNAemia 减少方面显示出有前途. 这项研究表明,LTV在这个脆弱人群中耐受性很好,对预防CMV有效.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 莱特莫维尔 (LTV) 已被批准用于成年血液细胞移植 (HCT) 接受者的细胞巨乳病毒 (CMV) 预防.
- 它在儿科HCT患者的使用是非标签的,支持文献有限.
研究的目的:
- 评估儿童HCT接受者的CMV感染LTV预防的疗效和安全性.
- 在LTV和非LTV预防组之间比较临床显著的CMVDNAemia的比率.
主要方法:
- 一个单中心,回顾性,匹配的 (1:1) 小儿科全基性HCT接受者的队列研究 (2015-2022年).
- 主要终点:移植后6个月内临床显著的CMVDNAemia (>1000副本/毫升或需要预防性治疗).
- 二次结局:DNAemia的时间,不良影响,以及与环素和沃里康纳的相互作用.
主要成果:
- 41名患者接受了LTV预防,与41名对照组相比.
- 在临床上显著的CMVDNAemia在LTV组中发生的频率较低 (9.8%与17.0%,p=0.33) 到第180天.
- 总体而言,LTV耐受性良好 (87.8%没有与药物相关的不良反应),并与利康纳低谷水平的降低有关.
结论:
- 在儿科HCT患者的LTV预防与临床显著的CMVDNAemia减少有关.
- 在这种人群中,LTV似乎是预防CMV的安全和潜在有效选择.
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