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在中华社区的轻度认知障碍患者中,在带膜-眼膜网络内的低连接性

Huan Yang¹, Xiaoyu Zhao², Tenglong Wang³

¹Department of Psychiatry, and National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

International journal of geriatric psychiatry

|August 7, 2023

概括

轻度认知障碍 (MCI) 与 cingulo-opercular 网络 (CON) 内的功能连接性降低有关. 这项研究强调了CON低连接性作为MCI的潜在生物标志物,与默认模式网络 (DMN) 不同.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医疗成像医学成像

背景情况:

休息状态的大脑活动形成了对认知至关重要的功能网络.
轻度认知障碍 (MCI) 涉及到大脑网络连接的变化.
在MCI中,了解 cingulo-opercular网络 (CON) 和默认模式网络 (DMN) 的变化至关重要.

研究的目的:

调查MCI个体中CON和DMN内部和之间休息状态功能连接的差异.
确定与MCI相关的特定网络连接模式.
探索MCI的认知功能 (ADAS-Cog) 和网络连接之间的关系.

主要方法:

使用了休息状态功能连接性分析.
参与者包括45名MCI患者 (60-83岁) 和70名年龄相匹配的健康对照.
用中国版本的阿尔茨海默病评估尺度-认知子尺度 (ADAS-Cog) 评估认知功能.

主要成果:

与健康对照组相比,MCI组在CON中表现出明显较低的功能连接性.
在DMN内部或在MCI组中CON和DMN之间,没有发现功能连接性的显著差异.
在患有MCI的个体中,没有观察到ADAS-Cog得分和网络内或网络之间的连接指标之间的相关性.

结论:

在CON电路中的低连接性可以作为MCI的特征标记.
这些发现增强了对MCI网络功能障碍的理解.
这些结果可以指导开发更有针对性的治疗干预措施MCI.

关键词:

皮带-骨干网络皮带-骨干网络默认模式网络模式默认模式网络模式功能连接性的功能连接性轻度的认知障碍轻度的认知障碍

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