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开发基于SEER数据库的预后诺姆图来预测同步多重原发性结肠直肠癌的整体生存率和癌症特异性生存率

Xiangyu Zhang¹, Yanpeng Hu¹, Kai Deng¹

¹Department of Gastrointestinal Surgery, Qilu Hospital of Shandong University Dezhou Hospital, 1751 Xinhu Street, Dezhou, 253000, China.

Journal of cancer research and clinical oncology

|August 7, 2023

概括

这项研究开发了一种新型的诺基图,用于预测同步多重原发性结直肠癌 (SMPCC) 患者的整体存活率 (OS) 和癌症特异性存活率 (CSS). 与TNM分期系统相比,名图提供了更好的临床决策.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
癌症预后癌症预后

背景情况:

同步多发性原发性结肠直肠癌 (SMPCC) 是罕见的,由多个同时或几乎同时发生的结肠直肠癌病变来定义.
准确的预后工具对于优化SMPCC患者的治疗策略至关重要.

研究的目的:

开发和验证一种用于预测SMPCC患者整体存活率 (OS) 和癌症特异性存活率 (CSS) 的新型名谱.
为了比较开发的诺姆图的临床实用性与已建立的TNM分期系统.

主要方法:

利用来自监测,流行病学和最终结果 (SEER) 数据库 (2004-2018) 的6772名SMPCC患者的数据.
采用单变量和多变量考克斯回归分析来确定独立的预后因素.
使用一致性指数 (C指数),校准曲线,ROC曲线和决策曲线分析 (DCA) 验证了名ogram.

主要成果:

确定了种族,婚姻状况,年龄,组织学,瘤位置,T,N,M阶段,化疗和淋巴结数作为独立的预后因素.
在训练队列中,名图表显示出良好的预测性能,C指数值为0.716 (OS) 和0.718 (CSS),在验证队列中为0.760 (OS) 和0.749 (CSS).
决策曲线分析表明,诺米图的临床净效益优于TNM分期系统.

结论:

开发了一种新的,可靠的诺姆图,用于预测SMPCC患者的OS和CSS.
这个工具可以帮助临床医生优化SMPCC的治疗决策.

关键词:

特定于癌症的生存率这个名字叫做Nomogram.总体生存率总体生存率塞尔·塞尔 (Seer) 是一个看得见的人.同步多重原发性结肠直肠癌.

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